Immunogold labelling of paired helical filaments and amyloid fibrils by specific monoclonal and polyclonal antibodies

@article{Reig1995ImmunogoldLO,
  title={Immunogold labelling of paired helical filaments and amyloid fibrils by specific monoclonal and polyclonal antibodies},
  author={Santiago Reig and Val{\'e}rie Bu{\'e}e-Scherrer and Andr{\'e} Defossez and Andr{\'e} Delacourte and Jean Claude Beauvillain and Michel Mazzuca and Chantal Mourton-Gilles},
  journal={Acta Neuropathologica},
  year={1995},
  volume={90},
  pages={441-447}
}
Senile plaque and paired helical filament (PHF) formation are characteristic of Alzheimer's disease, but the mechanisms leading to these lesions still remain unclear. To understand them better, we have performed different immunolabellings of amyloid protein and PHF. We describe a very specific immunodetection of PHF with AD2, a monoclonal antibody directed against a hyperphosphorylated epitope of PHF-tau, and use double immunolabelling to show that PHF and plaque amyloid are discretely labbeled… CONTINUE READING

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