Immunoglobulins on the Surface of Lymphocytes

  title={Immunoglobulins on the Surface of Lymphocytes},
  author={Emil R Unanue and Howard Grey and Enrique M. Rabellino and Priscilla A. Campbell and Jon R. Schmidtke},
  journal={The Journal of Experimental Medicine},
  pages={1188 - 1198}
Immunofluorescent studies using live cells from antibody-forming organs and anti-immunoglobulin antibodies demonstrate two populations of small lymphocytes which are differentiated by the presence or absence of Ig on their surface membranes. Most of the lymphocytes with detectable surface Ig appear to derive from cells of the bone marrow, while most of the Ig-negative lymphocytes derive from the thymus. Thus, adult mice thymectomized, lethally irradiated, and transplanted with bone marrow cells… CONTINUE READING

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