Immunoglobulin transcript sequence and somatic hypermutation computation from unselected RNA-seq reads in chronic lymphocytic leukemia.

@article{Blachly2015ImmunoglobulinTS,
  title={Immunoglobulin transcript sequence and somatic hypermutation computation from unselected RNA-seq reads in chronic lymphocytic leukemia.},
  author={James S. Blachly and Amy S. Ruppert and Weiqiang J Zhao and Susan K. De Long and Joseph M. Flynn and Ian W Flinn and Jeffrey A. Jones and Kami Maddocks and Leslie A. Andritsos and Emanuela M. Ghia and Laura Z. Rassenti and Thomas J. Kipps and Albert de la Chapelle and John C. Byrd},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 14},
  pages={4322-7}
}
Immunoglobulins (Ig) are produced by B lymphocytes as secreted antibodies or as part of the B-cell receptor. There is tremendous diversity of potential Ig transcripts (>1 × 10(12)) as a result of hundreds of germ-line gene segments, random nucleotide incorporation during joining of gene segments into a complete transcript, and the process of somatic hypermutation at individual nucleotides. This recombination and mutation process takes place in the maturing B cell and is responsible for the… CONTINUE READING
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