Immunoglobulin synthesis and secretion. VI. Synthesis and intracellular transport of immunoglobulin in nonsecretory lymphoma cells.

@article{Sherr1971ImmunoglobulinSA,
  title={Immunoglobulin synthesis and secretion. VI. Synthesis and intracellular transport of immunoglobulin in nonsecretory lymphoma cells.},
  author={Charles J Sherr and Jonathan W. Uhr},
  journal={The Journal of experimental medicine},
  year={1971},
  volume={133 4},
  pages={901-20}
}
Cells from an established line of Burkitt's lymphoma (Daudi) and a mouse myeloma (P(3)K) were pulse-labeled in vitro with (3)H-leucine, and immunoglobulin was immunologically precipitated from cell lysates and secretions. In contrast to P(3)K cells, Daudi cells synthesize a small amount of Ig which is not secreted. Subcellular fractionation experiments indicated that Ig of Daudi cells is synthesized on membrane-bound polyribosomes and enters the cisternae of the microsomes. Ig in the microsomes… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 64 references

The lymphocyte; its morphology and embryological origin

  • G. A. Ackerman
  • In Immunology and Haemopoiesis. J. M. Yoffey…
  • 1966
Highly Influential
4 Excerpts

Ultrastructural characteristics of surface IgM reactive malignant lymphoid cells

  • E. Hammond
  • Exp. Cell Res
  • 1970
Highly Influential
4 Excerpts

Antigen binding sites on mouse lymphoid cells

  • M. F. Greaves, N. M. Hogg
  • 1971

Similar Papers

Loading similar papers…