Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells

@article{Cooke1994ImmunoglobulinST,
  title={Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells},
  author={Michael P. Cooke and Andrew William Heath and Kevan M. Shokat and Yiming Zeng and Fred D. Finkelman and Peter S. Linsley and Maureen Howard and Christopher C. Goodnow},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={179},
  pages={425 - 438}
}
The specificity of antibody (Ab) responses depends on focusing helper T (Th) lymphocyte signals to suitable B lymphocytes capable of binding foreign antigens (Ags), and away from nonspecific or self-reactive B cells. To investigate the molecular mechanisms that prevent the activation of self-reactive B lymphocytes, the activation requirements of B cells specific for the Ag hen egg lysozyme (HEL) obtained from immunoglobulin (Ig)-transgenic mice were compared with those of functionally tolerant… CONTINUE READING
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