Immunoglobulin response to rabies virus immunization in dogs.

Nondescript dogs were inoculated with betapropiolactone-inactivated 5% sheep brain antirabies vaccine. The antibody response was found to show more IgM (19S) initially and more IgG (7S) latterly. A local strain of street rabies virus was used for postvaccinal challenge. The correlation between immunoglobulin response and protection were discussed.