Immunoglobulin-like transcript 3 is expressed by myeloid-derived suppressor cells and correlates with survival in patients with non-small cell lung cancer.

@article{Goeje2015ImmunoglobulinlikeT3,
  title={Immunoglobulin-like transcript 3 is expressed by myeloid-derived suppressor cells and correlates with survival in patients with non-small cell lung cancer.},
  author={Pauline L. de Goeje and Koen Bezemer and Marlies E. Heuvers and A. M. Dingemans and Harry J. M. Groen and Egbert F. Smit and Henk C. Hoogsteden and Rudi W Hendriks and Joachim G J V Aerts and Joost P. J. J. Hegmans},
  journal={Oncoimmunology},
  year={2015},
  volume={4 7},
  pages={e1014242}
}
Myeloid-derived suppressor cells (MDSCs) play an important role in immune suppression and accumulate under pathologic conditions such as cancer and chronic inflammation. They comprise a heterogeneous population of immature myeloid cells that exert their immunosuppressive function via a variety of mechanisms. Immunoglobulin-like transcript 3 (ILT3) is a receptor containing immunoreceptor tyrosine-based inhibition motifs (ITIMs) that can be expressed on antigen-presenting cells and is an… CONTINUE READING
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