Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of V kappa and V lambda segments and VJ combinations.

@article{Adderson1992ImmunoglobulinLC,
  title={Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of V kappa and V lambda segments and VJ combinations.},
  author={Elisabeth E. Adderson and Penelope G. Shackelford and Richard Insel and Anthony P. Quinn and Patricia M. Wilson and William L. Carroll},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={89 3},
  pages={
          729-38
        }
}
The immune repertoire to Haemophilus influenzae type b capsular polysaccharide (Hib PS) appears to be dominated by certain light chain variable region genes (IgVL). In order to examine the molecular basis underlying light chain bias, IgVL genes have been cloned from a panel of heterohybridomas secreting human anti-Hib PS (antibody) (anti-Hib PS Ab). One hybridoma, representative of the predominant serum clonotype of anti-Hib PS Ab in older children and adults following immunization or Hib… CONTINUE READING

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