Immunoglobulin light chain gene rearrangements display hierarchy in absence of selection for functionality in precursor-B-ALL

Abstract

The general order of the immunoglobulin (Ig) gene rearrangement process in human precursor-B cells is largely known. However, the exact Ig rearrangement patterns reflecting this process, especially those of the Ig light chain genes, are not well established. This requires detailed analysis of the gene configuration of all six IGH, IGK and IGL alleles at the… (More)
DOI: 10.1038/sj.leu.2402548

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@article{Burg2002ImmunoglobulinLC, title={Immunoglobulin light chain gene rearrangements display hierarchy in absence of selection for functionality in precursor-B-ALL}, author={M. J. M. van der Burg and B H Barendregt and Tomasz Szczepanski and ER van Wering and A A J Langerak and J. M. van Dongen}, journal={Leukemia}, year={2002}, volume={16}, pages={1448-1453} }