Immunoglobulin isotype switching in xid mice.

  title={Immunoglobulin isotype switching in xid mice.},
  author={Kurt A. Brorson and Michael V. Krasnokutsky and Kathryn E. Stein},
  journal={Molecular immunology},
  volume={32 7},
Mice with the x-linked immunodeficiency mutation (xid) are unresponsive to polysaccharide antigens, lack a subset of B cells, and have low serum IgM (2-20% of normal) and IgG3 (3% of normal). Because of the disproportionate reduction of IgG3, the ability of B cells from xid mice to switch to gamma 3 was examined. Switching was indirectly measured by comparing IgG3 production and C gamma 3 mRNA steady state levels of purified B cells activated to switch to IgG3 by LPS in bulk culture. Direct… CONTINUE READING

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