Immunoglobulin isotype distribution of antinuclear antibodies in dogs with leishmaniasis.

@article{Lucena1998ImmunoglobulinID,
  title={Immunoglobulin isotype distribution of antinuclear antibodies in dogs with leishmaniasis.},
  author={Rosario Angulo Lucena and Pedro J Ginel},
  journal={Research in veterinary science},
  year={1998},
  volume={65 3},
  pages={205-7}
}
A modified indirect immunofluorescence method, using rat liver as substrate, was developed to determine the immunoglobulin isotypes forming antinuclear antibodies in sera from 12 antinuclear antibody-positive dogs out of 121 dogs with natural Leishmania infection. Immunoglobulin M was found to be the most frequent component of antinuclear antibodies (91.7 per cent), followed by IgG (41.7 per cent) and IgA (33.2 per cent). When these immunoglobulin isotypes were titrated, IgG antinuclear… CONTINUE READING

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