Immunoglobulin heavy chain variable region gene usage in bone marrow transplant recipients: lack of somatic mutation indicates a maturational arrest.

@article{Suzuki1996ImmunoglobulinHC,
  title={Immunoglobulin heavy chain variable region gene usage in bone marrow transplant recipients: lack of somatic mutation indicates a maturational arrest.},
  author={Iwao Suzuki and E. C. Milner and Annuska M. Glas and W O Hufnagle and Sambasiva P. Rao and Leonhard Pfister and Carol N Nottenburg},
  journal={Blood},
  year={1996},
  volume={87 5},
  pages={1873-80}
}
Many recipients of bone marrow transplant (BMT) make normal amounts of serum immunoglobulin but are deficient in generating specific antibody responses to exogenous stimuli. To determine if abnormal usage of VH genes contributes to this immunodeficiency, the usage of VH genes was determined in peripheral blood B cells of four BMT recipients, two of whom had developed chronic graft versus host disease. The pattern of usage of VH3 or VH4 genes assessed at either 90 days or approximately 1 year… CONTINUE READING

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