Immunoglobulin heavy chain gene regulation through polyadenylation and splicing competition.


The immunoglobulin heavy chain (IgH) genes, which encode one of the two chains of antibody molecules, were the first cellular genes shown to undergo developmentally regulated alternative RNA processing. These genes produce two different mRNAs from a single primary transcript. One mRNA is cleaved and polyadenylated at an upstream poly(A) signal while the… (More)
DOI: 10.1002/wrna.36


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