Immunoglobulin heavy-chain gene rearrangement in adult acute lymphoblastic leukemia reveals preferential usage of J(H)-proximal variable gene segments.

@article{Mortuza2001ImmunoglobulinHG,
  title={Immunoglobulin heavy-chain gene rearrangement in adult acute lymphoblastic leukemia reveals preferential usage of J(H)-proximal variable gene segments.},
  author={Forida Y Mortuza and Ilidia M Moreira and Maria L Papaioannou and Paula Gameiro and Luke Anthony Coyle and Clair S Gricks and Peter L. Amlot and Hugh Grant Prentice and A. V. Delfin Madrigal and Allan Victor Hoffbrand and Letizia Foroni},
  journal={Blood},
  year={2001},
  volume={97 9},
  pages={2716-26}
}
The aim of this study was to characterize individual-segment and overall patterns of V(H) gene usage in adult B-lineage acute lymphoblastic leukemia (ALL). Theoretical values of V(H) segment usage were calculated with the assumption that all V(H) segments capable of undergoing rearrangement have an equal probability of selection for recombination. Leukemic clones from 127 patients with adult B-lineage acute leukemias were studied by fingerprinting by means of primers for the framework 1 and… CONTINUE READING

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