Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma.

@article{Gonzalez2007ImmunoglobulinGR,
  title={Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma.},
  author={David Gonzalez and Mirjam van der Burg and Ram{\'o}n Garc{\'i}a-Sanz and James A. L. Fenton and Anton W. Langerak and Marcos Gonz{\'a}lez and Jacques J.M. van Dongen and Jes{\'u}s F. San Miguel and Gareth J. Morgan},
  journal={Blood},
  year={2007},
  volume={110 9},
  pages={
          3112-21
        }
}
The ability to rearrange the germ-line DNA to generate antibody diversity is an essential prerequisite for the production of a functional repertoire. While this is essential to prevent infections, it also represents the "Achilles heel" of the B-cell lineage, occasionally leading to malignant transformation of these cells by translocation of protooncogenes into the immunoglobulin (Ig) loci. However, in evolutionary terms this is a small price to pay for a functional immune system. The study of… 
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This Review discusses end-stage high-risk disease states and how new information is improving the understanding of their evolutionary trajectories, how they may be diagnosed and the biological behaviour that must be addressed if they are to be treated effectively.
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