Immunoglobulin deposition in sural nerves of AIDS patients with distal-symmetric HIV-associated polyneuropathy.

@article{Rickert2002ImmunoglobulinDI,
  title={Immunoglobulin deposition in sural nerves of AIDS patients with distal-symmetric HIV-associated polyneuropathy.},
  author={Christian H. Rickert and St Evers and Ch Heese and Doris Reichelt and I. W. Husstedt},
  journal={European journal of medical research},
  year={2002},
  volume={7 11},
  pages={472-6}
}
The most frequent neurological diagnosis in peripheral nerve function of HIV-positive individuals is distal-symmetric polyneuropathy (DSPN). In this study we investigated the histopathology as well as the immunohistochemical expression of immunoglobulins IgA, IgG and IgM in post-mortem sural nerve tissue gained from 11 patients who had suffered from DSPN in the clinical course of AIDS (CDC 3C). We found that all 11 sural nerves showed signs of demyelination while in 6 out of 11 cases axonal… CONTINUE READING