Immunoglobulin class commitment exhibited by B lymphocytes separated according to surface isotype.

@article{Teale1981ImmunoglobulinCC,
  title={Immunoglobulin class commitment exhibited by B lymphocytes separated according to surface isotype.},
  author={Judy M. Teale and D E Lafrenz and Norman R. Klinman and Samuel Strober},
  journal={Journal of immunology},
  year={1981},
  volume={126 5},
  pages={1952-7}
}
In order to determine the extent to which B cells exhibit class commitment, the isotype(s) secreted by individual B cells and their progeny was studied in relation to the isotype(s) expressed on the surface of the B cell. Both primary and secondary B cells were separated according to cell surface isotypes and analyzed under optimal stimulation conditions using the T-dependent splenic focus assay. From these studies the following conclusions conclude be made: a) essentially all mature primary B… CONTINUE READING

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