Immunoglobulin Structure and Function as Revealed by Electron Microscopy

@article{Roux1999ImmunoglobulinSA,
  title={Immunoglobulin Structure and Function as Revealed by Electron Microscopy},
  author={K. Roux},
  journal={International Archives of Allergy and Immunology},
  year={1999},
  volume={120},
  pages={85 - 99}
}
  • K. Roux
  • Published 1999
  • Biology, Medicine
  • International Archives of Allergy and Immunology
    • Electron–microscopic (EM) analysis preceded crystallographic analysis [1, 2]of Igs by over a decade and was for a time the only direct way of analyzing their 3–D molecular structure. Once the X–ray structures were deduced, the role of EM gradually shifted from gross structural analysis to the addressing of more sophisticated structural and functional questions. EM remains a vital adjunct to the many physicochemical, biochemical, and serological tools brought to bear on these remarkable… CONTINUE READING
    View on PubMed
    bio.fsu.edu
    70 Citations
    Highly Influential Citations
    7
    Background Citations
    26
    Methods Citations
    2
    70 Citations
    Citation Type

    Citation Type

    Structure and flexibility of individual immunoglobulin G molecules in solution.
    • 136
    Protein ultrastructure and the nanoscience of complement activation.
    • 16
    Thermodynamic and structural characterization of an antibody gel
    • 14
    Dynamics of antibodies from cryo-electron tomography.
    • 17
    Dynamics of antibodies from cryo-electron tomography
    • PDF
    Structural Investigation of Antigens Using Electron Microscopy
    • Highly Influenced
    • PDF
    Freezing immunoglobulins to see them move.
    • 61
    • PDF
    Resolving the geometry of biomolecules imaged by cryo electron tomography
    • 4
    • Highly Influenced
    • PDF
    Tracking down the molecular architecture of the synaptonemal complex by expansion microscopy
    • 2
    • PDF
    The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen
    • 38

    References

    SHOWING 1-10 OF 89 REFERENCES
    Electron microscopic studies of mouse immunoglobulin M; structure and reconstitution following reduction.
    • 73
    Dynamic aspects of antibody structure.
    • 20
    Identification of a Fab interaction footprint site on an icosahedral virus by cryoelectron microscopy and X-ray crystallography
    • 78
    • PDF
    Visualization of natural autoantibody polyreactivity by rotary metal-shadowing electron microscopy.
    • 3
    Three-dimensional structure of an intact human immunoglobulin.
    • 302
    • PDF
    Concerning the axial rotational flexibility of the Fab regions of immunoglobulin G.
    • 23
    THE THREE‐DIMENSIONAL CONFORMATION OF γ M and γ A GLOBULIN MOLECULES
    • 93
    Xenopus laevis 19S immunoglobulin. Ultrastructure and J chain isolation.
    • 27
    Computer models of the human immunoglobulins shape and segmental flexibility.
    • R. Pumphrey
    • Computer Science, Medicine
    • Immunology today
    • 1986
    • 64
    Comparative electron microscopic studies of single biomolecules negatively stained and freeze-dried metal-shadowed.
    • 8