Immunoglobulin Structure and Function as Revealed by Electron Microscopy

  title={Immunoglobulin Structure and Function as Revealed by Electron Microscopy},
  author={Kenneth H. Roux},
  journal={International Archives of Allergy and Immunology},
  pages={85 - 99}
  • K. Roux
  • Published 1 October 1999
  • Chemistry
  • International Archives of Allergy and Immunology
Electron–microscopic (EM) analysis preceded crystallographic analysis [1, 2]of Igs by over a decade and was for a time the only direct way of analyzing their 3–D molecular structure. Once the X–ray structures were deduced, the role of EM gradually shifted from gross structural analysis to the addressing of more sophisticated structural and functional questions. EM remains a vital adjunct to the many physicochemical, biochemical, and serological tools brought to bear on these remarkable… 

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