Immunoglobulin M oligoclonal bands: Biomarker of targetable inflammation in primary progressive multiple sclerosis

  title={Immunoglobulin M oligoclonal bands: Biomarker of targetable inflammation in primary progressive multiple sclerosis},
  author={Luisa Mar{\'i}a Villar and Bonaventura Casanova and Nadia Ouamara and Manuel Comabella and Farzaneh Jalili and David Leppert and Clara de Andr{\'e}s and Guillermo Izquierdo and R. Garc{\'i}a Arroyo and Timucin Avşar and Sergey Vladimirovich Lapin and Trina A. Johnson and Xavier Montalban and {\'O}scar Fern{\'a}ndez and Roberto {\'A}lvarez-Lafuente and Donna L. Masterman and Mar{\'i}a I. Garc{\'i}a‐S{\'a}nchez and Francisco Coret and Aksel Siva and Evgeniy Evdoshenko and Jos{\'e} C. {\'A}lvarez-cerme{\~n}o and Amit Bar-Or},
  journal={Annals of Neurology},
To identify a biomarker distinguishing patients who, despite a primary progressive multiple sclerosis (PPMS) clinical course, may nonetheless benefit from immune therapy. 
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Lipid-specific immunoglobulin M in CSF predicts adverse long-term outcome in multiple sclerosis
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Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS.
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Changes in B- and T-lymphocyte and chemokine levels with rituximab treatment in multiple sclerosis.
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Oligoclonal bands and cerebrospinal fluid markers in multiple sclerosis: associations with disease course and progression
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Intrathecal IgM synthesis is a prognostic factor in multiple sclerosis
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