Immunoglobulin G3 monoclonal antibody directed to Tn antigen (tumor-associated alpha-N-acetylgalactosaminyl epitope) that does not cross-react with blood group A antigen.

Abstract

An IgG3 monoclonal antibody (CU-1) directed to the Tn glycoprotein antigen, which does not cross-react with blood group A antigen, has been established after immunization of mice with a purified Tn antigen, followed by selection of hybridomas secreting antibodies with the desired specificity. The antibody binding with Tn antigen was inhibited by… (More)

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