Immunoglobulin G3 blocking antibodies to the fungal pathogen Cryptococcus neoformans

@article{Nussbaum1996ImmunoglobulinGB,
  title={Immunoglobulin G3 blocking antibodies to the fungal pathogen Cryptococcus neoformans},
  author={Gabriel Nussbaum and R Yuan and Arturo Casadevall and Matthew D. Scharff},
  journal={The Journal of Experimental Medicine},
  year={1996},
  volume={183},
  pages={1905 - 1909}
}
Vaccination and infection can elicit protective and nonprotective antibodies to the fungus Cryptococcus neoformans in mice. The effect of nonprotective antibodies on host defense is unknown. In this study we used mixtures of protective and nonprotective monoclonal antibodies (mAbs) to determine if nonprotective mAbs blocked the activity of the protective mAbs. Antibody isotype and epitope specificity are important in determining the ability to prolong survival in mice given a lethal C… CONTINUE READING