Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: a model for autoimmune fetal loss.

@article{Branch1990ImmunoglobulinGF,
  title={Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: a model for autoimmune fetal loss.},
  author={David Ware Branch and Donald J. Dudley and Murray David Mitchell and K A Creighton and Thomas M Abbott and Elizabeth H. Hammond and Raymond A. Daynes},
  journal={American journal of obstetrics and gynecology},
  year={1990},
  volume={163 1 Pt 1},
  pages={210-6}
}
We determined whether purified immunoglobulin G from patients with antiphospholipid antibodies causes fetal loss in pregnant mice. Sera were obtained from nonpregnant parous women (group 1) and nonpregnant women with antiphospholipid antibodies and a history of fetal loss (group 2). Pregnant BALB/c mice were given an intraperitoneal injection of 15 mg of IgG on day 8 of pregnancy. Typically, mice treated with IgG from antiphospholipid antibodies aborted within 48 hours. When animals were… CONTINUE READING

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