Immunoglobulin E receptor-activated calcium conductance in rat mast cells.

  title={Immunoglobulin E receptor-activated calcium conductance in rat mast cells.},
  author={Lei Zhang and Michael A McCloskey},
  journal={The Journal of physiology},
  volume={483 ( Pt 1)},
1. The nystatin perforated-patch method was used to record macroscopic currents from anti-trinitrophenyl (TNP) immunoglobulin E (IgE)-sensitized rat basophilic leukaemia (RBL-2H3) cells at 37 degrees C. 2. An inwardly rectifying Ca2+ current (ICa) was activated upon stimulation with the multivalent antigen trinitrophenylated bovine serum albumin (TNP-BSA). Induction of ICa was not observed at room temperature. ICa was reversed and reinduced upon cyclical addition of the monovalent hapten… CONTINUE READING


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