Immunoglobulin E deficiency: a forgotten clue pointing to possible immunodeficiency?

@article{Unsworth2011ImmunoglobulinED,
  title={Immunoglobulin E deficiency: a forgotten clue pointing to possible immunodeficiency?},
  author={David Joseph Unsworth and Paul F Virgo and Robert John Lock},
  journal={Annals of clinical biochemistry},
  year={2011},
  volume={48 Pt 5},
  pages={459-61}
}
BACKGROUND Patients with primary antibody deficiency often have delayed diagnosis. Very low IgE, found during investigations for allergy, may be a marker for other immunodeficiency. METHODS We introduced a new laboratory policy of testing cases with very low IgE levels for possible linked antibody deficiency. The data represent an audit of routine results collected over two years. RESULTS Very low IgE (≤2 IU/mL) was identified in 85/2622 (3.2%) routine patient samples. Two children and four… CONTINUE READING