Immunoglobulin E, a pathogenic factor in Plasmodium falciparum malaria.

@article{Perlmann1997ImmunoglobulinEA,
  title={Immunoglobulin E, a pathogenic factor in Plasmodium falciparum malaria.},
  author={Peter Perlmann and Hedvig Perlmann and B. W{\aa}hlin Flyg and Margareta Hagstedt and Gehad E.B. Elghazali and S. G. Worku and V{\'i}ctor Diego Fresno Fern{\'a}ndez and Acleus S. M. Rutta and Marita Troye-Blomberg},
  journal={Infection and immunity},
  year={1997},
  volume={65 1},
  pages={
          116-21
        }
}
Most children and adults living in areas where the endemicity of Plasmodium falciparum malaria is high have significantly elevated levels of both total immunoglobulin E (IgE) and IgE antimalarial antibodies in blood. This elevation is highest in patients with cerebral malaria, suggesting a pathogenic role for this immunoglobulin isotype. In this study, we show that IgE elevation may also be seen in severe malaria without cerebral involvement and parallels an elevation of tumor necrosis factor… CONTINUE READING

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