Immunoglobulin A-mediated protection against Bordetella pertussis infection.

@article{Hellwig2001ImmunoglobulinAP,
  title={Immunoglobulin A-mediated protection against Bordetella pertussis infection.},
  author={Sandra M. M. Hellwig and Annemiek B van Spriel and Joop F. P. Schellekens and Frits R. Mooi and Jan G. J. van de Winkel},
  journal={Infection and immunity},
  year={2001},
  volume={69 8},
  pages={4846-50}
}
Infection with Bordetella pertussis, the causative agent of pertussis (whooping cough) in humans, is followed by the production of antibodies of several isotypes, including immunoglobulin A (IgA). Little is known, however, about the role of IgA in immunity against pertussis. Therefore, we studied targeting of B. pertussis to the myeloid receptor for IgA, FcalphaRI (CD89), using either IgA purified from immune sera of pertussis patients or bispecific antibodies directed against B. pertussis and… CONTINUE READING

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Therefore , we studied targeting of B. pertussis to the myeloid receptor for IgA , FcalphaRI ( CD89 ) , using either IgA purified from immune sera of pertussis patients or bispecific antibodies directed against B. pertussis and FcalphaRI ( CD89 BsAb ) .
Therefore , we studied targeting of B. pertussis to the myeloid receptor for IgA , FcalphaRI ( CD89 ) , using either IgA purified from immune sera of pertussis patients or bispecific antibodies directed against B. pertussis and FcalphaRI ( CD89 BsAb ) .
Infection with Bordetella pertussis , the causative agent of pertussis ( whooping cough ) in humans , is followed by the production of antibodies of several isotypes , including immunoglobulin A ( IgA ) .
Therefore , we studied targeting of B. pertussis to the myeloid receptor for IgA , FcalphaRI ( CD89 ) , using either IgA purified from immune sera of pertussis patients or bispecific antibodies directed against B. pertussis and FcalphaRI ( CD89 BsAb ) .
Therefore , we studied targeting of B. pertussis to the myeloid receptor for IgA , FcalphaRI ( CD89 ) , using either IgA purified from immune sera of pertussis patients or bispecific antibodies directed against B. pertussis and FcalphaRI ( CD89 BsAb ) .
Infection with Bordetella pertussis , the causative agent of pertussis ( whooping cough ) in humans , is followed by the production of antibodies of several isotypes , including immunoglobulin A ( IgA ) .
Both IgA and CD89 BsAb facilitated FcalphaRI - mediated binding , phagocytosis , and bacterial killing by human polymorphonuclear leukocytes ( PMNL ) and PMNL originating from human FcalphaRI - transgenic mice .
Infection with Bordetella pertussis , the causative agent of pertussis ( whooping cough ) in humans , is followed by the production of antibodies of several isotypes , including immunoglobulin A ( IgA ) .
Therefore , we studied targeting of B. pertussis to the myeloid receptor for IgA , FcalphaRI ( CD89 ) , using either IgA purified from immune sera of pertussis patients or bispecific antibodies directed against B. pertussis and FcalphaRI ( CD89 BsAb ) .
Therefore , we studied targeting of B. pertussis to the myeloid receptor for IgA , FcalphaRI ( CD89 ) , using either IgA purified from immune sera of pertussis patients or bispecific antibodies directed against B. pertussis and FcalphaRI ( CD89 BsAb ) .
Therefore , we studied targeting of B. pertussis to the myeloid receptor for IgA , FcalphaRI ( CD89 ) , using either IgA purified from immune sera of pertussis patients or bispecific antibodies directed against B. pertussis and FcalphaRI ( CD89 BsAb ) .
Therefore , we studied targeting of B. pertussis to the myeloid receptor for IgA , FcalphaRI ( CD89 ) , using either IgA purified from immune sera of pertussis patients or bispecific antibodies directed against B. pertussis and FcalphaRI ( CD89 BsAb ) .
Both IgA and CD89 BsAb facilitated FcalphaRI - mediated binding , phagocytosis , and bacterial killing by human polymorphonuclear leukocytes ( PMNL ) and PMNL originating from human FcalphaRI - transgenic mice .
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