Immunogenicity of transgenic plant-derived hepatitis B surface antigen.

  title={Immunogenicity of transgenic plant-derived hepatitis B surface antigen.},
  author={Yasmin Thanavala and Yanfen Yang and Patricia Lyons and Hugh S Mason and Charles J. Arntzen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={92 8},
The focus of the Children's Vaccine Initiative is to encourage the discovery of technology that will make vaccines more readily available to developing countries. Our strategy has been to genetically engineer plants so that they can be used as inexpensive alternatives to fermentation systems for production of subunit antigens. In this paper we report on the immunological response elicited in vivo by using recombinant hepatitis B surface antigen (rHBsAg) purified from transgenic tobacco leaves… CONTINUE READING