Immunogenicity of synthetic HIV-1 gp120 V3-loop peptide-conjugate immunogens.

Abstract

A successful prophylactic human immunodeficiency virus type 1 (HIV-1) vaccine must elicit an immune response that will prevent establishment of the persistent viral infection. The only response shown to be effective in this regard is virus-neutralizing antibody directed against the viral gp120 hypervariable V3-loop region. Conjugate immunogens, containing… (More)

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