Immunogenicity of recombinant type IX collagen in murine collagen-induced arthritis.

@article{Myers2002ImmunogenicityOR,
  title={Immunogenicity of recombinant type IX collagen in murine collagen-induced arthritis.},
  author={Linda Kay Myers and Tero Pihlajamaa and David D Brand and M. A. Cremer and M. Wernli. E. Bodo and Leena M Ala-Kokko and Andrew Kang},
  journal={Arthritis and rheumatism},
  year={2002},
  volume={46 4},
  pages={
          1086-93
        }
}
OBJECTIVE Past attempts to isolate type IX collagen (CIX) from cartilage using limited proteolysis yielded partially degraded material. Recent application of recombinant technology, however, has allowed the preparation of intact native CIX. We used the murine collagen-induced arthritis model to characterize the immunologic properties of recombinant human CIX (rCIX) produced using a baculovirus expression system. METHODS A panel of B10 congenic mice was immunized with rCIX emulsified with… CONTINUE READING
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