Immunogenicity of protein therapeutics: The key causes, consequences and challenges.

@article{Baker2010ImmunogenicityOP,
  title={Immunogenicity of protein therapeutics: The key causes, consequences and challenges.},
  author={Matthew P. Baker and Helen M Reynolds and Brooke Lumicisi and Christine J. Bryson},
  journal={Self/nonself},
  year={2010},
  volume={1 4},
  pages={314-322}
}
The immunogenicity of protein therapeutics has so far proven to be difficult to predict in patients, with many biologics inducing undesirable immune responses directed towards the therapeutic resulting in reduced efficacy, anaphylaxis and occasionally life threatening autoimmunity. The most common effect of administrating an immunogenic protein therapeutic is the development of a high affinity anti-therapeutic antibody response. Furthermore, it is clear from clinical studies that protein… CONTINUE READING