Immunogenicity of peptides for B cells is not impaired by overlapping T-cell epitope topology.

@article{Harris1996ImmunogenicityOP,
  title={Immunogenicity of peptides for B cells is not impaired by overlapping T-cell epitope topology.},
  author={D P Harris and Hans Martin Vordermeier and A Arya and Kenneth G. Bogdan and Christopher Moreno and Juraj Iv{\'a}nyi},
  journal={Immunology},
  year={1996},
  volume={88 3},
  pages={
          348-54
        }
}
The epitope specificity of T-cell help to B cells and of surface immunoglobulin-mediated B-cell-binding of antigens usually involves topographically distinct antigenic determinants. The possibility of cross-recognition of the same peptide sequence by both T cells and antibodies has been a matter of conflicting opinions. We investigated this subject by detailed mapping of T- and B-cell epitopes within four immunogenic mycobacterial peptides. The identified core sequences of T- and B-cell… CONTINUE READING

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