Immunogenicity of human embryonic stem cell-derived beta cells

@article{Torren2016ImmunogenicityOH,
  title={Immunogenicity of human embryonic stem cell-derived beta cells},
  author={C. R. van der Torren and A. Zaldumbide and G. Duinkerken and S. H. Brand-Schaaf and M. Peakman and G. Stang{\'e} and L. Martinson and E. Kroon and E. Brandon and D. Pipeleers and B. Roep},
  journal={Diabetologia},
  year={2016},
  volume={60},
  pages={126 - 133}
}
Aims/hypothesisTo overcome the donor shortage in the treatment of advanced type 1 diabetes by islet transplantation, human embryonic stem cells (hESCs) show great potential as an unlimited alternative source of beta cells. hESCs may have immune privileged properties and it is important to determine whether these properties are preserved in hESC-derived cells.MethodsWe comprehensively investigated interactions of both innate and adaptive auto- and allo-immunity with hESC-derived pancreatic… Expand
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