Immunogenicity of anti-TNF biologic therapies for rheumatoid arthritis

  title={Immunogenicity of anti-TNF biologic therapies for rheumatoid arthritis},
  author={Pauline A. van Schouwenburg and Theo Rispens and Gerrit Jan J Wolbink},
  journal={Nature Reviews Rheumatology},
Currently, five anti-TNF biologic agents are approved for the treatment of rheumatoid arthritis (RA): adalimumab, infliximab, etanercept, golimumab and certolizumab pegol. Formation of anti-drug antibodies (ADA) has been associated with all five agents. In the case of adalimumab and infliximab, immunogenicity is strongly linked to subtherapeutic serum drug levels and a lack of clinical response, but for the other three agents, data on immunogenicity are scarce, suggesting that further research… CONTINUE READING
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