Immunogenicity of a reduced schedule of pneumococcal conjugate vaccine in healthy infants and correlates of protection for serotype 6B in the United Kingdom.

@article{Goldblatt2010ImmunogenicityOA,
  title={Immunogenicity of a reduced schedule of pneumococcal conjugate vaccine in healthy infants and correlates of protection for serotype 6B in the United Kingdom.},
  author={David Goldblatt and Jo Southern and Lindsey Ashton and Nick Andrews and Sarah Woodgate and Polly Burbidge and Pauline A. Waight and Elizabeth Miller},
  journal={The Pediatric infectious disease journal},
  year={2010},
  volume={29 5},
  pages={401-5}
}
BACKGROUND Pneumococcal conjugate vaccine (PCV) was introduced in the United Kingdom immunization schedule in September 2006. This study was conducted to establish the immunogenicity of licensed PCV (Prevenar) at a reduced, 2 priming dose schedule (2+1) and to evaluate functional responses in the context of vaccine effectiveness. METHODS Infants were randomized to receive PCV at 2 and 3 months or 2 and 4 months of age. Boosters were administered at the same time as Haemophilus influenzae type… CONTINUE READING
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