Immunogenicity of a plasmid DNA vaccine encoding chimeric idiotype in patients with B-cell lymphoma.

  title={Immunogenicity of a plasmid DNA vaccine encoding chimeric idiotype in patients with B-cell lymphoma.},
  author={John M. Timmerman and Gita Singh and Gary Hermanson and Peter M. Hobart and Debra Katherine Czerwinski and Behnaz Taidi and Ranjani Rajapaksa and Clemens B Caspar and Adrienne van Beckhoven and Ronald Levy},
  journal={Cancer research},
  volume={62 20},
B-cell lymphomas express tumor-specific immunoglobulin, the variable regions of which [idiotype (Id)] can serve as a target for active immunotherapy. Promising results have been obtained in clinical studies of Id vaccination using Id proteins.However, Id protein is laborious and time-consuming to produce. DNA vaccination is an attractive alternative for delivering Id vaccines, because Id DNA can be rapidly isolated by PCR techniques. DNA coding for lymphoma Id can provide protective immunity in… CONTINUE READING
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