Immunogenicity of a hepatitis B DNA vaccine administered to chronic HBV carriers.

  title={Immunogenicity of a hepatitis B DNA vaccine administered to chronic HBV carriers.},
  author={Maryline Mancini-Bourgine and H{\'e}l{\`e}ne Fontaine and Christian Br{\'e}chot and Stanislas Pol and M E Michel},
  volume={24 21},
Hepatitis B virus (HBV) is the major pathogen of chronic hepatitis and liver disease worldwide. Despite the availability of effective vaccines against hepatitis B for many years, over 370 million people remain persistently infected with HBV. Viral persistence is thought to be related to poor HBV-specific T-cell responses. Based on clinical data, the development of efficient methods capable of inducing strong T-cell responses is an important and primary step toward the development of… CONTINUE READING


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