Immunogenicity of a Meningococcal B Vaccine during a University Outbreak.

  title={Immunogenicity of a Meningococcal B Vaccine during a University Outbreak.},
  author={Nicole E. Basta and Adel A F Mahmoud and Julian Wolfson and Alexander Ploss and Brigitte L Heller and Sarah Hanna and Peter Johnsen and Robin Izzo and Bryan T. Grenfell and Jamie Findlow and Xilian Bai and Ray Borrow},
  journal={The New England journal of medicine},
  volume={375 3},
BACKROUND In December 2013, a multicomponent meningococcal serogroup B (4CMenB) vaccine was used before licensure on the basis of special consideration by the Food and Drug Administration to respond to an outbreak of Neisseria meningitidis B at a U.S. university. Data suggested that vaccination would control the outbreak because isolates expressed antigens that were closely related to the vaccine antigens (factor H-binding protein [fHbp] and neisserial heparin-binding antigen). We quantified… CONTINUE READING


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