Immunogenicity of HIV-1 envelope glycoprotein oligomers.

  title={Immunogenicity of HIV-1 envelope glycoprotein oligomers.},
  author={Mattias N. E. Forsell and William R. Schief and Richard T. Wyatt},
  journal={Current opinion in HIV and AIDS},
  volume={4 5},
PURPOSE OF REVIEW We summarize and discuss recent developments regarding the immunogenicity of human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) oligomers, focusing, for the most part, on trimeric, recombinant protein immunogens. RECENT FINDINGS The three-dimensional cryo-electron tomography images of the HIV-1 Env trimeric spike, coupled with previous data demonstrating the impact on envelope glycoprotein (gp120)-transmembrane glycoprotein (gp41) cleavage of the… CONTINUE READING