Immunogenicity and reactogenicity of a reduced-antigen-content diphtheria-tetanus-acellular pertussis vaccine as a single-dose booster in Singaporean adults.

@article{Chan2006ImmunogenicityAR,
  title={Immunogenicity and reactogenicity of a reduced-antigen-content diphtheria-tetanus-acellular pertussis vaccine as a single-dose booster in Singaporean adults.},
  author={S. H. Chan and Poh Tin Tan and Htay Htay Han and Hans Ludwig Bock},
  journal={Singapore medical journal},
  year={2006},
  volume={47 4},
  pages={286-90}
}
INTRODUCTION Older children and adults, susceptible to pertussis because of waning immunity, may serve as a reservoir of infection, leading to severe disease among young unvaccinated infants. Booster diphtheria-tetanus-acellular pertussis (dTpa) vaccination in older age groups is rare in Singapore, one reason being the increase in reactogenicity with each successive dose. The aim of this study was to assess the immunogenicity, safety and reactogenicity of a reduced antigen, combined dTpa… CONTINUE READING

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