Immunogenicity and protective efficacy of the Mycobacterium tuberculosis fadD26 mutant.

@article{Infante2005ImmunogenicityAP,
  title={Immunogenicity and protective efficacy of the Mycobacterium tuberculosis fadD26 mutant.},
  author={Eduardo R Mar{\'i}n Infante and Leon Diana Aguilar and B. Gicquel and Rogelio Hern{\'a}ndez Pando},
  journal={Clinical and experimental immunology},
  year={2005},
  volume={141 1},
  pages={21-8}
}
The Mycobacterium tuberculosis fadD26 mutant has impaired synthesis of phthiocerol dimycocerosates (DIM) and is attenuated in BALB/c mice. Survival analysis following direct intratracheal infection confirmed the attenuation: 60% survival at 4 months post-infection versus 100% mortality at 9 weeks post-infection with the wild-type strain. The fadD26 mutant induced less pneumonia and larger DTH reactions. It induced lower but progressive production of interferon (IFN)-gamma, interleukin (IL)-4… CONTINUE READING