Immunogenicity and protective efficacy of a vaccine prepared from 53 kDa truncated hepatitis E virus capsid protein expressed in insect cells.

@article{Zhang2001ImmunogenicityAP,
  title={Immunogenicity and protective efficacy of a vaccine prepared from 53 kDa truncated hepatitis E virus capsid protein expressed in insect cells.},
  author={Mingdong Zhang and Suzanne U. Emerson and Hanh Nguyen and Ronald E Engle and Sugantha Govindarajan and John L. Gerin and Robert H. Purcell},
  journal={Vaccine},
  year={2001},
  volume={20 5-6},
  pages={853-7}
}
Hepatitis E virus (HEV) is an enterically transmitted virus that causes acute hepatitis. Expression of recombinant HEV capsid protein in insect cells results in two major proteolytically-processed products of 56 and 53kDa which consist of amino acids (aa) 112-607 and 112-578, respectively. The only neutralization epitope identified to date is located at least partially between amino acids 578 and 607 meaning it should be present only in the 56 and not in the 53kDa protein. Previously, it was… CONTINUE READING

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