Immunogenicity and efficacy in aotus monkeys of four recombinant Plasmodium falciparum vaccines in multiple adjuvant formulations based on the 19-kilodalton C terminus of merozoite surface protein 1.

@article{Kumar2000ImmunogenicityAE,
  title={Immunogenicity and efficacy in aotus monkeys of four recombinant Plasmodium falciparum vaccines in multiple adjuvant formulations based on the 19-kilodalton C terminus of merozoite surface protein 1.},
  author={Sanjai Kumar and William Collins and A Egan and Anjali Yadava and Olivier Garraud and Michael J. Blackman and Jos{\'e} A. Guevara Pati{\~n}o and Carter L. Diggs and David C Kaslow},
  journal={Infection and immunity},
  year={2000},
  volume={68 4},
  pages={2215-23}
}
The immunogenicity and protective efficacy of four versions of recombinant C-terminal 19-kDa epidermal growth factor-like region of the major surface protein 1 (rMSP1(19)) of Plasmodium falciparum was studied in Aotus monkeys. Vaccination with each of the four rMSP1(19) constructs elicited high levels of antibodies to MSP1(19) but only one construct, the 19-kDa fragment expressed as a secreted fusion protein from Saccharomyces cerevisiae (yP30P2MSP1(19)), induced a high degree of protective… CONTINUE READING
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