Immunogenicity and efficacy against lethal aerosol staphylococcal enterotoxin B challenge in monkeys by intramuscular and respiratory delivery of proteosome-toxoid vaccines.

@article{Lowell1996ImmunogenicityAE,
  title={Immunogenicity and efficacy against lethal aerosol staphylococcal enterotoxin B challenge in monkeys by intramuscular and respiratory delivery of proteosome-toxoid vaccines.},
  author={George H. Lowell and C A Colleton and Denzil Frost and Robert W Kaminski and Michael Hughes and Jeremy J. Hatch and Craig Hooper and J. Scot Estep and Linsey Pitt and M. Topper and Robert E Hunt and William Baker and Wallace B. Baze},
  journal={Infection and immunity},
  year={1996},
  volume={64 11},
  pages={4686-93}
}
Staphylococcal enterotoxin B (SEB), a primary cause of food poisoning, is also a superantigen that can cause toxic shock after traumatic or surgical staphylococcal wound [correction of would] infections or viral influenza-associated staphylococcal superinfections or when aerosolized for use as a potential biologic warfare threat agent. Intranasal or intramuscular (i.m.) immunization with formalinized SEB toxoid formulated with meningococcal outer membrane protein proteosomes has previously been… CONTINUE READING