Immunogenicity and characterization of WRSF2G11: a second generation live attenuated Shigella flexneri 2a vaccine strain.

Abstract

Recent clinical trials involving live attenuated Shigella vaccine strains SC602 and WRSS1 have revealed that deletion of the virG(icsA) gene dramatically reduces virulence in human volunteers. These strains can be given at low oral doses and induce a strong, and in some cases, protective immune responses. However, residual vaccine associated reactogenicity… (More)

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@article{Ranallo2007ImmunogenicityAC, title={Immunogenicity and characterization of WRSF2G11: a second generation live attenuated Shigella flexneri 2a vaccine strain.}, author={Ryan T. Ranallo and Sejal Thakkar and Qing Chen and M. Venkatesan}, journal={Vaccine}, year={2007}, volume={25 12}, pages={2269-78} }