Immunogenicity Studies of Bivalent Inactivated Virions of EV71/CVA16 Formulated with Submicron Emulsion Systems

@inproceedings{Lin2014ImmunogenicitySO,
  title={Immunogenicity Studies of Bivalent Inactivated Virions of EV71/CVA16 Formulated with Submicron Emulsion Systems},
  author={Chih-Wei Lin and Chia-Chyi Liu and Tsung-Chun Lu and Shih-Jen Liu and York Chow and Pele Chong and Ming-Hsi Huang},
  booktitle={BioMed research international},
  year={2014}
}
We assessed two strategies for preparing candidate vaccines against hand, foot, and mouth disease (HFMD) caused mainly by infections of enterovirus (EV) 71 and coxsackievirus (CV) A16. We firstly design and optimize the potency of adjuvant combinations of emulsion-based delivery systems, using EV71 candidate vaccine as a model. We then perform immunogenicity studies in mice of EV71/CVA16 antigen combinations formulated with PELC/CpG. A single dose of inactivated EV71 virion (0.2 μg) emulsified… CONTINUE READING

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