Immunogenicity Studies in Carnivores Using a Rabies Virus Construct with a Site-Directed Deletion in the Phosphoprotein

@inproceedings{Vos2011ImmunogenicitySI,
  title={Immunogenicity Studies in Carnivores Using a Rabies Virus Construct with a Site-Directed Deletion in the Phosphoprotein},
  author={Ad Vos and Karl-Klaus Conzelmann and Stefan Finke and Thomas M{\"u}ller and Jens Peter Teifke and Anthony R Fooks and Andreas Neubert},
  booktitle={Advances in preventive medicine},
  year={2011}
}
Different approaches have been applied to develop highly attenuated rabies virus vaccines for oral vaccination of mesocarnivores. One prototype vaccine construct is SAD dIND1, which contains a deletion in the P-gene severely limiting the inhibition of type-1 interferon induction. Immunogenicity studies in foxes and skunks were undertaken to investigate whether this highly attenuated vaccine would be more immunogenic than the parental SAD B19 vaccine strain. In foxes, it was demonstrated that… CONTINUE READING