Immunogenic cell death modalities and their impact on cancer treatment

  title={Immunogenic cell death modalities and their impact on cancer treatment},
  author={Oliver Kepp and Antoine Tesni{\`e}re and Fr{\'e}d{\'e}ric Schlemmer and Micka{\'e}l Michaud and Laura Senovilla and Laurence Zitvogel and Guido Kroemer},
It is still enigmatic under which circumstances cellular demise induces an immune response or rather remains immunologically silent. Moreover, the question remains open under which circumstances apoptotic, autophagic or necrotic cells are immunogenic or tolerogenic. Although apoptosis appears to be morphologically homogenous, recent evidence suggests that the pre-apoptotic surface-exposure of calreticulin may dictate the immune response to tumor cells that succumb to anticancer treatments… CONTINUE READING