Immunogenetic risks of anti-cyclical citrullinated peptide antibodies in a North American Native population with rheumatoid arthritis and their first-degree relatives.

@article{ElGabalawy2009ImmunogeneticRO,
  title={Immunogenetic risks of anti-cyclical citrullinated peptide antibodies in a North American Native population with rheumatoid arthritis and their first-degree relatives.},
  author={H El-Gabalawy and D. Robinson and Deborah J. Hart and Brenda Elias and Janet Markland and C. Peschken and Irene Smolik and G. MONTES-ALDANA and Marial-Louise Schroeder and M J Fritzler and M Cheang and Kiem Oen},
  journal={The Journal of rheumatology},
  year={2009},
  volume={36 6},
  pages={
          1130-5
        }
}
OBJECTIVE To determine the prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in unaffected relatives of North American Native probands with rheumatoid arthritis (RA); and the associations of the shared epitope (SE) and HLA-DRB1*0901 with RA and anti-CCP antibodies. METHODS The subjects were RA probands, affected relatives, unaffected first-degree (FDR) and more distant relatives, and unaffected controls from the same population. HLA-DRB1 typing was determined by DNA… CONTINUE READING

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