Immunogenetic risk factors for anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis.

@article{Genk1999ImmunogeneticRF,
  title={Immunogenetic risk factors for anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis.},
  author={Martin Gen{\vc}{\'i}k and Stefan Borgmann and Roland Zahn and Ekkehard D. Albert and Thomas Sitter and Joerg T. Epplen and Harald Fricke},
  journal={Clinical and experimental immunology},
  year={1999},
  volume={117 2},
  pages={
          412-7
        }
}
Wegener's granulomatosis (WG) and microscopic polyangiitis are systemic autoimmune diseases characterized by the presence of ANCA in the sera of patients. Little is known about the aetiologic factors and genetic predisposition as well as the pathogenesis of these disease entities. A slightly decreased representation of HLA-DRB1*13 and HLA-DQB1*0603 individuals was observed in our cohort of ANCA-associated systemic vasculitis (AASV) patients compared with controls. In addition, HLA-DRB1*04… CONTINUE READING
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