Immunogenetic factors in HPV-associated cervical cancer: influence on disease progression.

  title={Immunogenetic factors in HPV-associated cervical cancer: influence on disease progression.},
  author={Maggie F. Duggan-Keen and Peter J. Keating and Fabrice Stevens and Paul Sinnott and Peter J. F. Snijders and Jan M. M. Walboomers and Susan Elizabeth Davidson and R. Douglas Hunter and P. Dyer and Peter L. Stern},
  journal={European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics},
  volume={23 4},
No HLA allele or specificity was significantly different in frequency between a group of 150 cervical cancer patients from north-west England and controls (corrected P values). HLA-DRB1*1501/DQB1*0602 was non-significantly increased, particularly among patients with HPV16-positive tumours. HLA-B7-positive patients had a significantly poorer clinical outcome than HLA-B7-negative patients. A significant component of the genotypic effect is down-regulation of HLA-B7 expression by the tumour cells.